The National Center for Integrative Biomedical Informatics (NCIBI) is one of seven National Centers for Biomedical Computing (NCBC) within the NIH Roadmap. The NCBC program is focused on building a universal computing infrastructure designed to speed progress in biomedical research. NCIBI was founded in September 2005 and is based at the University of Michigan as part of the Center for Computational Medicine and Bioinformatics (CCMB).

Led jointly by teams of computational and biomedical scientists, NCIBI:

Integrates vast amounts of diverse, multi-scale data and derived knowledge, including context-appropriate molecular biology information from emerging experimental data; gene, protein, and metabolite databases; and the published literature.

Collaborates to determine how these data sets can best be represented and developed into resources that will advance research and facilitate biomedical discoveries.

Creates relevant tools for analytically exploring the data to uncover and validate functional associations and possible causal and conditional relationships involved in mechanisms of complex physiological processes or diseases.

Develops an array of tutorials, seminars, documentation, and other training materials to assure both the usability and usefulness of NCIBI tools.

Disseminates discoveries and processes to biomedical communities worldwide through publications, presentations, national partnerships and collaborators, and e-networking initiatives such as an RSS feed and the NCIBI gateway.

News

Dr. Eva Feldman discusses new stem cell treatment on cnn.com video

Gilbert S. Omenn named president of U.S. Human Proteome Organization

NCIBI researchers discover new fusion gene related to lung cancer

NIH, the NephCure Foundation and U of M support kidney study

New Tools and Services

The Biositemaps Working Group is proud to announce the 2.0 release of the Resource Discovery System, which allows searching over 1400 biositemap resources developed by different biomedical organizations, centers and research programs. Biositemaps represent a mechanism for computational biologists and bio-informaticians to openly broadcast and retrieve meta-data about biomedical resources. NCIBI resources are listed here.

Now available, APIs for the following resources:

Gene2MeSH: http://gene2mesh.ncibi.org/about.html#programmatic
MiMI: http://mimi.ncibi.org/MimiWeb/ws/about_mimi.html
NLP: http://nlp.ncibi.org/about.html

Upcoming Events

12th RCMI International Symposium, Nashville, Tennessee - December 6-10, 2010

Recent Programs and Presentations

The 23rd International Conference on Computational Linguistics, Beijing, China - August 23-27, 2010
Citation Summarization Through Keyphrase Extraction (V. Qazvinian, D. Radev, A. Ozgur)

NCIBI/RCMI Summer Workshop, Ann Arbor, MI - July 29-30, 2010

Cytoscape Consortium Summer Retreat, Ann Arbor, MI - July 18-20, 2010

ISMB 2010, Boston, MA - July 11-13, 2010
Using the NCIBI Suite of Integrated Tools and Data (J. Cavalcoli)

RECENT Publications

BN+1 bayesian network expansion for identifying molecular pathway elements. Hodges AP, Woolf P, and He Y. (Communicative & Integrative Biology. November/December 2010)

Linking variants from genome-wide association analysis to function via transcriptional network analysis. Keller B, Martini S, Sedor J, Kretzler M. (Semin Nephrol. March 2010)

Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks. Gao J, Tarcea VG, Karnovsky A, Mirel BR, Weymouth TE, Beecher CW, Cavalcoli JD, Athey BD, Omenn GS, Burant CF, Jagadish HV. (Bioinformatics. Apr 1, 2010)